NECROSIS - PATHOLOGY - EASYMEDNOTES 2021
NECROSIS Any Disturbances from external environment beyond the limits of homeostasis can lead to premature cell death, known as necrosis. Necrosis may be caused by ischaemia, infection, poisoning etc. Types The types of necrosis include: • Coagulative necrosis • Liquefactive necrosis • Fat necrosis • Caseous necrosis • Gangrenous necrosis Coagulative Necrosis It is the common type of necrosis and it is caused by ischaemic injury which results in hypoxic death of cells in all tissues except the brain. On gross examination, the affected tissue will be pale in colour and firm in texture. Microscopically, increased eosinophilia of the cytoplasm and decreased basophilia of the nucleus are seen. Liquefactive Necrosis This occurs in situations in which enzymatic breakdown is more prominent than protein denaturation unlike coagulative necrosis. It is usually associated with bacterial or fungal infections because microbes stimulate the accumulation...